Regonat Regorafenib – 40 mg (1 pack / 28 tablets)

At a Glance

Generic Name: Regorafenib

Brand Name: Regonat

Strength & Pack Size: Regonat 40 mg – 1 pack / 28 tablets

Dosage Form: Oral film-coated tablets

Therapeutic Class: Multikinase inhibitor, targeted anticancer therapy

Main Indications: Metastatic colorectal cancer, unresectable gastrointestinal stromal tumours (GIST) and hepatocellular carcinoma as indicated

Use in Therapy: Systemic oral treatment for unresectable or metastatic disease after prior lines of therapy

Prescription Status: Prescription-only oncology medicine

Supplied By: Licensed manufacturers and authorised distributors

Storage: Store below 25 °C in a dry place, protected from light and moisture

Product Description

Regonat 40 mg contains regorafenib, an oral multikinase inhibitor used as targeted therapy in selected patients with advanced solid tumours.
It is commonly prescribed for metastatic colorectal cancer, unresectable gastrointestinal stromal tumours (GIST) and hepatocellular carcinoma after
standard options have failed or are no longer effective. Regonat regorafenib 40 mg tablets act on multiple signalling pathways involved in tumour growth and tumour angiogenesis,
helping to slow disease progression under specialist supervision.

Each Regonat 40 mg tablet contains 40 mg of regorafenib, and the 1 pack / 28 tablets presentation aligns with typical 28-day treatment cycles
(three weeks on therapy followed by one week off) used in many protocols. As a generic regorafenib 40 mg product, Regonat offers the same active ingredient and strength
as originator regorafenib while providing a more accessible price in USD for patients requiring repeated cycles of targeted therapy.

When you buy Regonat 40 mg online from Generic Meds Mart, you receive regorafenib 40 mg tablets in original manufacturer packaging with clear labelling, batch number and expiry date.
We source Regonat only from licensed manufacturers and authorised distributors that follow recognised GMP standards. Our role is limited to safe, structured supply; all treatment decisions remain with your oncology team.

Key Uses

Regonat 40 mg regorafenib tablets are generally used under specialist supervision for:

• Metastatic colorectal cancer in adults previously treated with standard chemotherapy and targeted agents
• Unresectable or metastatic gastrointestinal stromal tumours (GIST) after failure or intolerance of other tyrosine kinase inhibitors
• Hepatocellular carcinoma in patients who have received prior systemic therapy when regorafenib is recommended

Your oncologist will determine whether Regonat 40 mg is appropriate based on tumour type, prior treatments, liver function and current guidelines.

How Regorafenib Works in Chemotherapy

Regorafenib is an oral targeted anticancer medicine from the class of multikinase inhibitors.
Although often grouped with modern systemic chemotherapy, Regonat regorafenib does not act like classic cytotoxic drugs that directly damage DNA.
Instead, it blocks multiple protein kinases that regulate tumour cell proliferation and tumour blood vessel formation.

Regonat 40 mg regorafenib tablets inhibit kinases including RAF family members and receptors in the VEGFR and PDGFR pathways.
These kinases drive tumour growth and angiogenesis in many colorectal cancers, GIST and hepatocellular carcinomas. By targeting these pathways,
Regonat 40 mg exerts both antiproliferative and anti-angiogenic effects, helping to slow tumour growth and reduce tumour blood supply.

Because these pathways also exist in healthy tissues, regorafenib therapy can cause systemic side effects, making regular monitoring by an experienced oncologist essential throughout treatment.

Dosage & Administration

The dosing schedule for Regonat 40 mg regorafenib tablets must always follow your oncology team’s instructions.
Many regorafenib protocols use a 28-day cycle with treatment given for three weeks followed by a one-week break, but exact doses and cycle numbers vary.

• Take Regonat tablets exactly as prescribed, at the same time each treatment day.
• Swallow Regonat 40 mg tablets whole with water; do not crush, split or chew them unless your pharmacist advises otherwise.
• Your doctor may recommend taking regorafenib 40 mg after a low-fat meal to support consistent absorption.
• Do not change the number of tablets, alter cycle patterns or stop Regonat on your own.
• If you miss a dose, follow written instructions from your treatment centre; do not double the next dose unless your doctor specifically instructs you to.

Regular blood tests, blood pressure checks and clinical visits are required so your oncology team can assess response and adjust Regonat 40 mg therapy if needed.

Precautions

Before starting Regonat 40 mg, tell your doctors about your full medical history and all medicines, supplements and herbal products you use. Important precautions include:

• Pre-existing liver disease, cirrhosis, viral hepatitis or abnormal liver function tests
• History of hypertension, coronary artery disease, heart failure or arterial clotting events
• Recent major surgery or planned operations, due to potential effects on wound healing
• Previous bleeding disorders, gastrointestinal ulcers, perforation or varices
• Use of anticoagulants or antiplatelet medicines that may increase bleeding risk
• Use of strong inducers or inhibitors of drug-metabolising enzymes that may alter regorafenib levels
• Pregnancy or breastfeeding; regorafenib tablets are not recommended and may harm an unborn baby

Men and women of child-bearing potential are usually advised to use effective contraception during and for a period after Regonat regorafenib treatment, as directed by their oncologist.

Regorafenib Side Effects

Common side effects

Common side effects of Regonat 40 mg regorafenib tablets include:

• Hand–foot skin reaction (redness, pain, thickening on palms and soles)
• Rash, dry skin or itching
• Fatigue, asthenia or low energy
• Diarrhea or loose stools
• Nausea, occasional vomiting or reduced appetite
• Abdominal discomfort or pain
• Hoarseness or voice changes
• Mild to moderate increases in blood pressure

These effects are often manageable with supportive care, blood pressure control, dermatologic treatment and dose modifications, as decided by your oncology team.

Serious side effects

Serious side effects of regorafenib require urgent medical attention and may include:

• Severe or uncontrolled hypertension, chest pain or shortness of breath
• Significant bleeding, such as black or bloody stools, vomiting blood or coughing up blood
• Signs of severe liver injury: yellowing of the skin or eyes, dark urine, pale stools, intense upper abdominal pain
• Severe, persistent abdominal pain that may indicate gastrointestinal perforation
• Severe hand–foot skin reaction with blistering or extensive peeling
• Sudden severe headache, vision changes or neurological symptoms suggestive of a vascular event

If you experience any of these symptoms while taking Regonat 40 mg, seek emergency medical care immediately and contact your oncology team.

Storage

• Store Regonat 40 mg regorafenib tablets at room temperature, preferably below 25 °C.
• Keep tablets in their original blisters and carton to protect them from moisture and light.
• Keep all anticancer medicines out of the sight and reach of children and pets.
• Do not use after the expiry date printed on the packaging.

Ask your pharmacist or oncology centre how to safely dispose of unused or expired Regonat regorafenib tablets.

Why Buy from Generic Meds Mart

Generic Meds Mart is dedicated to providing safe access to key oncology medicines such as
Regonat 40 mg regorafenib tablets at transparent prices in USD.
We source only from licensed manufacturers and authorised distributors that comply with recognised GMP standards and maintain a reliable export record.

When you buy Regonat 40 mg online from Generic Meds Mart, you benefit from:

• Discreet, plain outer packaging for international delivery
• Clear, structured information about regorafenib 40 mg tablets to support discussions with your oncology team
• Tracked shipping options to many destinations
• Customer support for questions about ordering, payment and delivery

Order Now

Regonat 40 mg regorafenib tablets are prescription-only targeted anticancer medicines and must be used strictly under specialist supervision.
Before you order Regonat online, ensure your oncologist has confirmed regorafenib as part of your treatment plan and specified the total daily dose and number of packs required.

Select Regonat 40 mg (1 pack / 28 tablets), choose the quantity that matches your written plan, add it to your cart and complete the secure checkout on Generic Meds Mart.
Your order will be processed, packed discreetly and shipped with tracking where available. All treatment decisions and dose adjustments must remain with your healthcare team.