Pemnat 100 mg, 500 mg (Pemetrexed) Injections

Buy Pemnat 100 mg and 500 mg Pemetrexed Injection Vials Online

Pemnat 100 mg and 500 mg Pemetrexed Injection Vials

At a Glance

Generic Name: Pemetrexed

Brand Name: Pemnat

Strength & Pack Size: 100 mg and 500 mg single-use vials of pemetrexed powder for concentrate for solution for infusion

Dosage Form & Route: Lyophilised powder for IV infusion after reconstitution and dilution in a hospital setting

Therapeutic Class: Antifolate antineoplastic agent (platinum-based combination chemotherapy partner)

Primary Indication: Advanced non-small cell lung cancer and malignant pleural mesothelioma, according to protocol

Usual Adult Dose: Body surface area–based IV dose administered in cycles, as defined by an oncology specialist

Prescription Status: Prescription-only cytotoxic medicine for hospital or infusion centre use

Storage: Store vials below 25 °C, protect from light, follow local cytotoxic handling and disposal procedures

Product Description

Pemnat is a branded formulation of pemetrexed, an antifolate antineoplastic agent used as part of platinum-based chemotherapy regimens for advanced non-small cell lung cancer and malignant pleural mesothelioma. Supplied as lyophilised powder in 100 mg and 500 mg single-use vials, Pemnat is reconstituted and further diluted for intravenous infusion under strict hospital protocols. Pemetrexed has become an established component of several first-line and maintenance regimens in non-squamous non-small cell lung cancer and is also used in selected mesothelioma treatment schedules when recommended by international and local guidelines.

The availability of both 100 mg and 500 mg vial strengths allows oncology teams to construct precise, body surface area–based pemetrexed doses while minimising wastage. Typically, one or more 500 mg vials are combined with 100 mg vials to reach the required total dose per cycle, calculated from the patient’s height and weight. Pemnat is never self-administered; all preparation, dilution and infusion steps are carried out by trained pharmacy and nursing staff in cytotoxic handling environments.

Generic Meds Mart supplies Pemnat pemetrexed injection vials in original manufacturer cartons from licensed distributors. Each vial is accompanied by the official labelling that indicates strength, generic name, handling precautions, batch number, expiry date and storage conditions. Shipments are packed in neutral outer packaging that does not display oncology-related wording, while cold-chain or temperature-controlled procedures are observed where required according to the product information and supplier practice. Our role is limited to access and logistics; all decisions about pemetrexed use remain with your oncology team.

Key Uses

Pemnat vials are used in adults for the treatment of advanced or metastatic non-small cell lung cancer (NSCLC), particularly non-squamous histology, either in combination with a platinum agent such as cisplatin in the initial treatment setting or as single-agent therapy after prior chemotherapy when protocols support this approach. Pemetrexed-based regimens aim to improve disease control, prolong survival and relieve symptoms such as cough, breathlessness and pain in appropriately selected patients.

Pemnat is also used in malignant pleural mesothelioma, a rare but aggressive cancer of the pleural lining often associated with asbestos exposure. In this indication, pemetrexed is typically combined with cisplatin as part of first-line chemotherapy to help slow disease progression and support quality of life measures. The exact regimen, number of cycles, and use of maintenance pemetrexed, if any, depends on disease stage, performance status, organ function and local treatment guidelines, and must be determined by an experienced oncologist.

How Pemetrexed Works in Chemotherapy

Pemetrexed, the active ingredient in Pemnat, is a multi-targeted antifolate that interferes with key enzymes involved in folate-dependent metabolic pathways required for DNA and RNA synthesis. By inhibiting enzymes such as thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase, pemetrexed disrupts the production of thymidine and purine nucleotides that rapidly dividing tumour cells rely on to replicate.

Because cancer cells often have higher proliferation rates and increased folate pathway activity compared with normal tissues, they can be particularly susceptible to antifolate-induced growth arrest and cell death. When pemetrexed is combined with platinum agents like cisplatin, which cause DNA crosslinking and damage, the dual stress on DNA production and repair can enhance cytotoxicity against tumour cells. At the same time, pemetrexed’s effect on normal tissues, especially bone marrow and gastrointestinal mucosa, underlies many of its predictable side effects, which are managed through dose adjustments, folic acid and vitamin B12 supplementation and careful monitoring.

Dosage & Administration

Pemnat dosing is based on body surface area and is always prescribed and administered by oncology specialists familiar with pemetrexed protocols and cytotoxic handling requirements. The contents of each Pemnat vial are reconstituted with an appropriate diluent to form a concentrate, which is then further diluted in an infusion bag containing a compatible solution. The final solution is infused intravenously over a specified period, often around 10 minutes or longer depending on institutional practice, in a hospital or infusion centre with resuscitation facilities.

Before each treatment cycle, patients typically undergo blood tests to assess kidney function, liver function and full blood counts, because pemetrexed clearance and toxicity are influenced by renal function and bone marrow reserve. Folic acid and vitamin B12 supplementation, along with premedication with corticosteroids, are standard components of pemetrexed therapy to reduce the risk of severe haematologic and non-haematologic toxicities and to lower the incidence of skin reactions. The exact dose per square metre, number of cycles and timing relative to platinum or other agents are defined by the oncologist according to local guidelines and individual clinical factors.

Precautions

Before starting Pemnat, your oncology team will carefully evaluate your overall health, including kidney function, liver function, performance status, nutritional status, concurrent medicines and any prior exposure to chemotherapy or radiotherapy. Significant renal impairment may require dose adjustment or alternative therapies, as pemetrexed is primarily excreted by the kidneys. Pemetrexed should not be given until adequate recovery from previous chemotherapy or radiation has occurred, and caution is required in patients with pre-existing bone marrow suppression or those at high risk for infection.

Non-steroidal anti-inflammatory drugs, particularly certain agents given around the time of pemetrexed administration, may affect pemetrexed clearance in patients with mild to moderate renal impairment and may need to be withheld around treatment days. Live vaccines are generally avoided during active cytotoxic chemotherapy. Pemetrexed is contraindicated in pregnancy unless the potential benefit outweighs the risk, and effective contraception is recommended for both women and men of reproductive potential during treatment and for a period afterwards, as defined in local product information. Breastfeeding is usually not recommended while receiving pemetrexed.

Pemetrexed Side Effects

Common side effects

Common side effects of pemetrexed include fatigue, nausea, vomiting, loss of appetite, diarrhoea or constipation, mild to moderate mucositis or mouth sores, rash or skin dryness, and reversible hair thinning. Blood tests often show lowered white blood cell counts, red blood cell counts and platelets, reflecting bone marrow suppression, which can lead to increased susceptibility to infections, anaemia-related tiredness and a tendency to bruise or bleed more easily. Many of these effects are manageable with supportive medicines, dose modifications and scheduled rest periods between cycles, and they are typically monitored closely through regular clinic visits and laboratory assessments.

Serious side effects

More serious side effects require urgent medical assessment and may necessitate dose reduction, delay or discontinuation of pemetrexed. These include severe neutropenia with fever or signs of infection, such as chills, persistent cough or shortness of breath; severe thrombocytopenia with unusual bleeding or petechiae; profound anaemia with shortness of breath, chest pain or dizziness; severe mucositis with difficulty eating or drinking; and significant kidney or liver dysfunction reflected in laboratory abnormalities and clinical symptoms such as reduced urine output, swelling, jaundice or abdominal pain. Rare but serious skin reactions, including extensive rash, blistering or peeling, can also occur. Any sudden or severe symptom during or after pemetrexed cycles should be reported immediately to the treating oncology team or emergency services.

Storage

Unopened Pemnat vials should be stored at controlled room temperature, generally below 25 degrees Celsius, protected from light and moisture, according to the manufacturer’s instructions. Vials should remain in their original cartons until they are removed for reconstitution in the pharmacy or chemotherapy preparation area. Once reconstituted and diluted, pemetrexed solutions have specific stability and storage limits that must be followed by hospital staff as described in the product information. Patients themselves are not expected to handle or store pemetrexed vials at home; all handling, preparation and disposal of Pemnat is carried out by trained healthcare professionals following cytotoxic safety procedures.

Why Buy from Generic Meds Mart

Generic Meds Mart focuses on supporting access to critical oncology medicines such as Pemnat pemetrexed injection vials for patients and clinics in regions where availability or pricing may be challenging. We work only with licensed manufacturers and authorised distributors who follow recognised quality standards and maintain traceable batch and expiry records. By supplying Pemnat 100 mg and 500 mg in original cartons, we enable oncology teams to verify product identity and integrity against their protocols and documentation.

All orders placed through Generic Meds Mart are processed in USD using secure online checkout, and shipments are prepared in neutral outer packaging without cancer-related markings to protect patient privacy. Where possible, tracked delivery options allow clinics and patients to plan chemotherapy cycles around anticipated delivery windows and minimise the risk of treatment delays due to supply interruptions. While we facilitate logistics and price transparency, decisions about whether pemetrexed is appropriate, how it is dosed and how long it is continued always rest with qualified oncology professionals.

Order Now

Before ordering Pemnat 100 mg or 500 mg vials from Generic Meds Mart, you should have a clearly documented treatment plan from an oncologist that specifies pemetrexed as part of your chemotherapy regimen, including dose, cycle frequency and expected number of cycles. Your oncology team will have reviewed your diagnostic imaging, tumour histology, staging, baseline laboratory tests and comorbidities before choosing pemetrexed-based therapy. Once your plan is established, you or your clinic can select the appropriate combination of Pemnat 100 mg and 500 mg vials to match the prescribed doses and add them to your cart for secure checkout.

You should never attempt to self-administer Pemnat or alter your treatment schedule without direct input from your oncology team. If you experience new or worsening symptoms during treatment, such as fever, unexpected bleeding, severe fatigue, shortness of breath or significant changes in kidney function markers, you should contact your cancer centre promptly rather than adjusting chemotherapy yourself. Generic Meds Mart exists to help ensure that the medicines specified in your regimen are available in a timely, discreet and verifiable way, while the clinical management of your cancer remains firmly in the hands of your treating specialists.

FAQ about Pemnat (Pemetrexed)

Q1: What cancers is Pemnat used to treat?

Pemnat contains pemetrexed, an antifolate chemotherapy drug primarily used in advanced non-small cell lung cancer, particularly non-squamous types, and in malignant pleural mesothelioma. It is usually given in combination with a platinum agent such as cisplatin in first-line regimens and may be used as single-agent maintenance or subsequent therapy in selected patients according to local protocols and specialist judgement.

Q2: How is Pemnat given during chemotherapy cycles?

Pemnat vials are reconstituted and diluted by hospital pharmacy staff and then administered as an intravenous infusion over a defined period, often on day one of a treatment cycle. Cycles are typically repeated every few weeks, with rest periods in between to allow blood counts and other parameters to recover. The exact schedule, including cycle length and the number of cycles, depends on the indication, combination partners and your individual response and tolerance.

Q3: Why do I need folic acid and vitamin B12 with Pemnat?

Pemetrexed interferes with folate-dependent pathways, and this can contribute to bone marrow suppression and other toxicities. Supplementing with folic acid and vitamin B12 before and during treatment has been shown to reduce the risk of severe side effects without compromising the antitumour effect. Your oncology team will typically prescribe a specific folic acid dose and schedule vitamin B12 injections around your pemetrexed cycles.

Q4: Can Pemnat be used if I have kidney problems?

Because pemetrexed is mainly cleared by the kidneys, reduced kidney function can increase drug exposure and the risk of toxicity. Mild to moderate renal impairment may require careful dose adjustment or additional monitoring, while more severe impairment may be a contraindication to treatment. Your oncologist will base the decision on your measured creatinine clearance or estimated glomerular filtration rate and may repeat kidney function tests regularly during therapy.

Q5: Will I lose my hair with Pemnat?

Pemetrexed can cause some hair thinning in certain patients, but it is generally associated with less severe hair loss than some other cytotoxic agents. The degree of hair loss varies from person to person and may also depend on other medicines in your regimen. Your oncology team can discuss what to expect in your particular case and suggest supportive measures for hair and scalp care during chemotherapy.