Zavedos Idarubicin – 5 mg Injection Vial

Buy Zavedos 5 mg Idarubicin Injection Online

Zavedos Idarubicin – 5 mg Injection Vial

At a Glance

Generic Name: Idarubicin Hydrochloride

Brand Name: Zavedos 5 mg

Strength & Pack Size: 5 mg idarubicin per vial, 1 single-use vial

Dosage Form & Route: Lyophilised powder for solution for IV injection or infusion

Therapeutic Class: Anthracycline cytotoxic chemotherapy

Primary Indications: Induction and consolidation regimens for acute myeloid leukaemia (AML) and selected acute leukaemia protocols, according to local label

Typical Use in Therapy: Combined with other cytotoxics (such as cytarabine) in intensive hospital-based regimens under haematology supervision

Mode of Action: Intercalates DNA, inhibits topoisomerase II and generates free radicals, disrupting DNA replication and repair

Key Benefits: Established anthracycline backbone in many AML protocols when used with appropriate supportive care

Precautions: Risk of myelosuppression, cardiotoxicity, mucositis and organ toxicity; requires close monitoring in a specialist centre

Storage: Store as directed on the carton, usually below 25 °C, protected from light in the original outer pack

Product Description

Zavedos 5 mg contains idarubicin hydrochloride, an anthracycline cytotoxic medicine used predominantly in the treatment of acute myeloid leukaemia (AML) and selected acute leukaemia protocols. Each single-use vial provides 5 mg of idarubicin as a lyophilised powder that must be reconstituted with a suitable diluent before intravenous administration. Zavedos 5 mg idarubicin injection is restricted to hospital and specialist haematology settings, where experienced teams manage complex induction and consolidation chemotherapy with full access to supportive care.

In many treatment protocols, Zavedos 5 mg idarubicin injection is combined with cytarabine and other agents to achieve remission in AML. It may also appear in variations of acute leukaemia regimens depending on national guidelines, trial data and institutional practice. Because idarubicin is a potent anthracycline with the potential for both short-term and long-term toxicity, its use is carefully weighed against disease severity, patient fitness, prior anthracycline exposure and cardiac status. This is not a medicine for outpatient self-administration; every step from reconstitution to infusion is handled by trained oncology or haematology staff.

Generic Meds Mart supplies Zavedos 5 mg idarubicin injection only in original manufacturer packaging obtained from licensed distributors. Each vial is sealed and carries a clearly printed batch number and expiry date so hospital pharmacies can document traceability. Outer shipping cartons are neutral, without visible references to leukaemia, anthracyclines or idarubicin, helping protect privacy during international delivery. Pricing is shown in USD to support planning for multi-cycle chemotherapy that may involve several vials across induction and consolidation phases.

Key Uses

In clinical practice, Zavedos 5 mg idarubicin injection is used as part of combination chemotherapy for acute myeloid leukaemia and, in some settings, other acute leukaemias where idarubicin is incorporated into validated protocols. Typical uses include induction regimens aimed at achieving complete remission and consolidation courses designed to deepen and maintain the response.

The exact protocol, number of cycles and combination partners differ by region and institutional guidelines. Some centres reserve idarubicin for particular risk groups or disease subtypes, while others use it within standard AML induction regimens. Decisions about whether to use idarubicin rather than other anthracyclines such as daunorubicin are made by haematologists based on evidence, local practice, patient comorbidities and cumulative anthracycline exposure. Zavedos 5 mg is one component of a broader plan that may include further chemotherapy, stem cell transplantation or maintenance strategies.

How Idarubicin Works in Chemotherapy

Idarubicin, the active ingredient in Zavedos 5 mg injection, is an anthracycline antineoplastic agent. It exerts its cytotoxic effect through multiple mechanisms, including DNA intercalation, inhibition of topoisomerase II and generation of free radicals that damage cellular components. By intercalating between DNA base pairs, idarubicin disrupts DNA structure and interferes with replication and transcription. Topoisomerase II inhibition prevents the proper unwinding and re-ligation of DNA strands, further impairing replication and repair.

These actions are particularly harmful to rapidly dividing cells, such as leukaemic blasts in the bone marrow. When Zavedos 5 mg idarubicin injection is combined with other agents like cytarabine, the effects on DNA synthesis and repair can be synergistic, enhancing the likelihood of inducing remission. However, this same potency underlies the risk of damage to normal rapidly dividing cells, including bone marrow progenitors, gastrointestinal mucosa and hair follicles, as well as potential cumulative injury to cardiac tissue over time.

Dosage & Administration

Zavedos 5 mg idarubicin injection must only be prescribed and administered by haematologists or oncologists experienced in intensive leukaemia chemotherapy. Each vial contains 5 mg of idarubicin powder for reconstitution. The dose is typically calculated on the basis of body surface area (mg/m²) and administered intravenously over a defined time interval, often on specific days of a chemotherapy cycle alongside other agents.

Reconstitution and dilution are performed under aseptic, cytotoxic handling conditions in a pharmacy or chemotherapy preparation unit. Nurses trained in cytotoxic administration then deliver the dose via a central or peripheral venous line, monitoring for extravasation and infusion reactions. Zavedos 5 mg idarubicin injection is never given by the patient at home and must not be administered intramuscularly or subcutaneously. Frequent blood counts, biochemistry tests and clinical assessments guide decisions about subsequent doses, cycle timing and supportive interventions such as transfusions or growth factor support.

Precautions

Before initiating Zavedos 5 mg idarubicin injection, the treatment team reviews cardiac function, prior anthracycline exposure, liver and kidney function, performance status and infection risk. Anthracyclines are associated with dose-dependent cardiomyopathy, so baseline assessment of left ventricular ejection fraction is standard, with follow-up imaging where indicated. Patients with significant pre-existing cardiac disease may require alternative regimens or careful modification of anthracycline dosing.

Myelosuppression is expected and often profound, so patients receiving Zavedos 5 mg must be treated in centres capable of delivering transfusions, broad-spectrum antibiotics, antifungals, growth factors and intensive supportive care. Adequate liver and kidney function are important to handle metabolism and excretion of idarubicin and its metabolites. Fertility counselling is usually offered before treatment starts, and effective contraception is advised during therapy and for a period afterwards, as idarubicin is contraindicated in pregnancy and may harm an unborn child.

Idarubicin Side Effects

Common side effects

Common idarubicin side effects in patients receiving Zavedos 5 mg injection include myelosuppression with neutropenia, thrombocytopenia and anaemia; increased susceptibility to infections; hair loss; nausea and vomiting; mucositis affecting the mouth and gastrointestinal tract; diarrhoea or constipation; fatigue; and temporary changes in liver function tests. The urine or tears may take on a reddish colour for a short period due to the anthracycline pigment, which is usually benign but can be alarming if not anticipated.

With experienced supportive care, many of these common idarubicin side effects can be managed. Centres that use Zavedos 5 mg routinely will provide antiemetic regimens, oral care protocols, nutritional support and transfusion strategies. Patients and families are counselled on signs of infection, bleeding and dehydration so they can seek help promptly.

Serious side effects

Serious idarubicin adverse effects require immediate medical attention. These may include severe or prolonged bone marrow suppression leading to septic shock or major haemorrhage; clinically significant cardiotoxicity with heart failure symptoms; severe mucositis preventing oral intake; acute liver or kidney injury; and severe extravasation injury if the drug leaks from the vein into surrounding tissue. Anthracyclines have also been associated with secondary malignancies after long-term follow-up in some patients, though this risk must be weighed against the immediate need to treat life-threatening leukaemia.

Patients are instructed to contact the treatment centre or emergency services urgently if they develop high fever, chills, shortness of breath, chest pain, sudden weight gain with swelling, uncontrolled bleeding, severe mouth or throat pain, confusion, markedly reduced urine output or any other alarming symptom during or after a cycle containing Zavedos 5 mg idarubicin injection. The team may need to adjust further therapy, intensify supportive care or consider alternative regimens.

Storage

Zavedos 5 mg idarubicin injection vials should be stored exactly as described on the product carton and in the package leaflet, usually below 25 °C, protected from light in the original outer carton. Vials must be kept out of the sight and reach of children. Reconstituted solutions have a limited stability window and must be used or discarded according to cytotoxic preparation guidelines. Unused solution, vials, syringes and infusion lines that have come into contact with idarubicin should be disposed of as cytotoxic waste, following local regulations and institutional policies.

Why Buy from Generic Meds Mart

Generic Meds Mart is focused on structured access to key oncology medicines such as Zavedos 5 mg idarubicin injection. We partner only with licensed manufacturers and authorised distributors that comply with Good Manufacturing Practice and maintain full batch traceability. Each vial of Zavedos 5 mg supplied by Generic Meds Mart is delivered in sealed original packaging so hospital pharmacies can confirm brand, strength, batch number and expiry before release to the chemotherapy unit.

By listing Zavedos 5 mg in USD, we help treatment centres and patients plan for the cost of multi-cycle AML regimens that may require multiple vials. Neutral outer cartons protect confidentiality during international shipping, while tracking (where available) supports coordination between delivery and scheduled chemotherapy cycles. Our role is limited to supply and logistics; all decisions about when and how to use idarubicin remain strictly with the treating haematology or oncology team.

Order Now

Zavedos 5 mg idarubicin injection is a potent anthracycline cytotoxic medicine reserved for specialist use in acute leukaemia chemotherapy. It must never be ordered for unsupervised or home administration. Before arranging supply through Generic Meds Mart, the treating team should confirm the indication, planned protocol, number of cycles, required idarubicin dose per cycle, cumulative anthracycline limits and supportive care resources.

Once that plan is documented, a designated purchaser or pharmacist can calculate the number of Zavedos 5 mg vials needed for the initial induction and consolidation phases. They can then select the appropriate quantity on Generic Meds Mart, add it to the cart and complete secure checkout in USD. Vials will be shipped in discreet outer packaging with full original labelling inside. Patients and caregivers should direct all clinical questions about idarubicin, side effects or dose modifications to their haematology team and must not attempt to handle or administer Zavedos 5 mg themselves.

FAQ about Zavedos (Idarubicin)

Q1: What is Zavedos 5 mg used for?
Zavedos 5 mg contains idarubicin, an anthracycline cytotoxic agent used primarily in induction and consolidation protocols for acute myeloid leukaemia (AML) and selected acute leukaemia regimens, according to local product information and specialist guidelines.

Q2: Can Zavedos 5 mg be given outside hospital?
No. Zavedos 5 mg idarubicin injection is prepared and administered only in hospital or specialist centres with facilities for intensive chemotherapy, cytotoxic handling and full supportive care. It is not suitable for outpatient self-administration.

Q3: How is Zavedos 5 mg administered?
Each vial of Zavedos 5 mg idarubicin injection is reconstituted and further diluted as required, then given intravenously by trained staff. Doses are calculated in mg/m² as part of a larger chemotherapy regimen. Administration routes, infusion times and schedules must follow the official product information and institutional protocols.

Q4: Why is heart monitoring important with idarubicin?
Idarubicin, like other anthracyclines, can cause cumulative cardiotoxicity and may lead to reduced heart function or heart failure. Baseline and follow-up heart assessments, such as echocardiograms, help specialists track cardiac function and adjust anthracycline exposure to reduce risk while still treating the leukaemia effectively.

Q5: What should patients watch for during treatment with Zavedos 5 mg?
Patients and caregivers should pay close attention to fever, chills, signs of infection, unusual bleeding or bruising, severe mouth sores, persistent vomiting or diarrhoea, chest pain, shortness of breath, sudden swelling, profound fatigue or reduced urine output. Any such symptoms should prompt immediate contact with the treatment centre or emergency services, as they may indicate serious idarubicin-related complications.